Familial Clustering of Antiphospholipid Syndrome

Familial occurrence of the antiphospholipid syndrome.

In a family of four the whole spectrum of antiphospholipid and associated antibodies was present but without evidence of connective tissue disease. All four members had anticardiolipin antibodies; two had a confirmed lupus anticoagulant. Thrombocytopenia was severe in one and associated with a high titre of antiplatelet antibody, while another member was found to have a positive antiglobulin te...

Artherial thrombosis with antiphospholipid syndrome in 17 year old female patient: case of familial antiphospholipid syndrome

Background The Antiphospholipid syndrome is a multiorgan, autoimmune disorder characterized by repeated vascular thrombosis, pathologic pregnancies, thrombocytopenia and positive antiphospholipid antibodies (aPL), anticardiolipin antibodies (aCL) and/or anti-ß2 glycoprotein I antibodies (anti-ß2GP I). There is primary and secondary antiphospholipid syndrome, «catastrophic» and so called «famili...

Anticardiolipin syndrome: antiphospholipid syndrome.

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Antiphospholipid syndrome

APS can be primary or secondary. Primary antiphospholipid syndrome occurs in the absence of any other related disease. Secondary antiphospholipid syndrome is often associated with systemic lupus erythematosus and less frequently with infections, drugs and other diseases. Serologic markers are antiphospholipid antibodies, lupus anticoagulant and anticardiolipin. In rare cases, APS leads to rapid...

Antiphospholipid syndrome